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8486.    1. (300 words) Compare and contrast internal and external validity of research designs.  2. (300 words) What is the pros and cons to internal and external validity of research designs.  3. (300 words) How can internal and external validity of research designs benefit evidence base practice and the healthcare industry?  4. (500 words)  Find a study evidence base practice study related to the PICOT question below, and examine it to see which of the threats to internal and external validity is present in that study and why? Use APA 7th edition and at least four reference including the text book.  For immobile post-surgical client who are at an increased risk for deep venous thrombosis (P) how effective is the application of sequential compression devices (SCDs) (I) in comparison to leg exercises (C) in reducing the prevalence of deep vein thrombosis (O) within one month time (T)?



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