1458. Decision Point One Savella 12.5 mg once daily on day 1; followed by 12.5 mg BID on day 2 and 3; followed by 25 mg BID on days 4-7; followed by 50 mg BID thereafter RESULTS OF DECISION POINT ONE Client returns to clinic in four weeks Client comes into the office to without crutches but is limping a bit. The client states that the pain is more manageable since I started taking that drug. I have been able to get around more on my own. The pain is bad in the morning though and gets better throughout the day. On a pain scale of 1-10; the client states that his pain is currently a 4. When asked what pain level would be tolerable on a daily basis, the client states, I would rather have no pain but dont think that is possible. I could live with a pain level of 3.. When questioned further, the PMHNP asks what makes the pain on a scale of 1-10 different when comparing a level of 9 to his current level of 4?. The client states that since using this drug, I can get to a point on most days where I do not need the crutches. The client is also asked what would need to happen to get his pain from a current level of 4 to an acceptable level of 3. He states, If I could get to the point everyday where I do not need the crutches for most of my day, I would be happy. Client states that he has noticed that he frequently (over the past 2 weeks) gets bouts of sweating for no apparent reason. He also states that his sleep has not been so good as of lately. He does complain of nausea today Client’s blood pressure and pulse are recorded as 147/92 and 110 respectively. He also admits to experiencing butterflies in his chest. The client denies suicidal/homicidal ideation and is still future oriented Decision Point Two Continue with current medication but lower dose to 25 mg twice a day RESULTS OF DECISION POINT TWO Client returns to clinic in four weeks Client comes to office today with use of crutches. He states that his current pain is a 7 out of 10. I do not feel as good as I did last month. Client states that he is sleeping at night but woken frequently from pain down his right leg and into his foot Client’s blood pressure and heart rate recorded today are 124/85 and 87 respectively. He denies any heart palpitations today Client denies suicidal/homicidal ideation but he is discouraged about the recent slip in his pain management and looks sad Decision Point Three Change Savella to 25 mg orally in the MORNING and 50 mg orally at BEDTIME Guidance to Student The client has a complex neuropathic pain syndrome that may never respond to pain medication. Once that is understood, the next task is to explain to the client that pain level expectations need to realistic in nature and understand that he will always have some level of pain on a daily basis. The key is to manage it in a manner that allows him to continue his activities of daily living with as little discomfort as possible. Next, it is important to explain that medications are never the final answer but a part of a complex regimen that includes physical therapy, possible chiropractic care, heat and massage therapy, and medications. Savella is a SNRI that also possesses NMDA antagonist activity which helps in producing analgesia at the site of nerve endings. It is specifically marketed for fibromyalgia and has a place in therapy for this gentleman. Tramadol is never a good option along with other opioid type analgesics. Agonists at the Mu receptors does not provide adequate pain control in these types of neuropathic pain syndromes and therefore is never a good idea. It also has addictive properties which can lead to secondary drug abuse. Reductions in Savella can help control side effects but at a cost of uncontrolled pain. It is always a good idea to start with dose reductions during parts of the day that pain is most under control. The addition of Celexa with Savella needs to be done cautiously. Both medications inhibit the reuptake of serotonin and can, therefore, lead to serotonin toxicity or serotonin syndrome.